Russian Scientist: ‘We Know Everything About COVID-19, but We Know Nothing About It’

Russian scientists have suggested a computer-based approach to search for pharmacological substances for use in Covid-19 treatment. This was discussed at an online meeting organised by the Ministry of Science and Higher Education of the Russian Federation, the Russian Academy of Sciences and the Scientific Russia portal.

Coronavirus Contradictions

The coronavirus situation is dramatically affecting all aspects of human life.

More than 19,000 works on SARS-CoV-2/COVID-19 have been published over the past five months.

At the same time, he believes that the world is witnessing an unprecedented speed of scientific discoveries in the field of fighting the coronavirus. On 25 January, the first genome was deciphered. Today, there are several thousand decrypted genomes, and the work is still ongoing.

On 5 February, the first three-dimensional enzyme structure was obtained, which made it possible to further apply molecular modelling methods to search for corresponding anti-COVID-19 drugs. Understanding the virus’s structure and life cycle allows us to identify the most promising targets.

To give an example, the scientist cited a recent publication in The Lancet (one of the most famous medical journals) saying that using hydroxychloroquine and chloroquine (antimalarial drugs used to treat COVID-19) is not tenable.

The article collected extensive clinical material. However, a few days later, three of the article’s authors withdrew their names from it. “This example shows that the process is ongoing, and it is extremely controversial. We can evaluate many issues only post factum. But we cannot fight the virus post factum, we need to fight it now,” Vladimir Poroykov said.

“New” cure is long-forgotten old one

Due to the fact that it takes a lot of time to search and create vaccines, scientists are trying to reposition existing drugs. The first attempt to reposition a drug (Dipyridamole, a well-known antiplatelet agent) was made back in March when a computer programme showed that along with its antiplatelet effect, the drug inhibits the basic protease of the virus. 

This was confirmed in vitro, and Chinese scientists immediately moved to the testing stage. Two large research teams conducted a systematic drug search. One found 13 active compounds, while another one found 64.

The Orekhovich Institute of Biomedical Chemistry made its own attempt at drug repositioning. One of the drugs (Neratinib) was identified as a possible inhibitor of the virus’s main protease. This has now to be proved experimentally.

Computer forecasting

When the pandemic broke out, the Grand Challenge Against Covid-19 project was launched in Europe. The project organisers proposed six targets; substances should be found for these targets using three independent computer methods with more than 1 billion accessible structures, including drugs approved for medical use.

Headed by Vladimir Poroykov, Russian scientists, who have been developing PASS computer programmes for more than 30 years and predict more than 5,000 types of biological activity, have chosen 4 targets: the main protease, papain protease, RNA-dependent protease and human membrane protease, which helps the virus penetrate into the cell.

During the research, Russian scientists concluded that the pharmacotherapy problem needs to be comprehensively analyzed – from training samples preparation and training a special information-computing system to selecting promising molecules based on forecasting and testing.

According to experts, to obtain reliable results when searching for new drugs, everything should be as coordinated as possible.

Currently, more than 32 thousand molecules that can potentially affect the target have been selected, a machine analysis has been carried out and several potential inhibitors have been selected, for which molecular modelling showed good interaction with the main protease of the virus.

Sourse: sputniknews.com

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