The Pope rests after a night's sleep wearing a respirator mask while undergoing treatment in hospital for double pneumonia.
The latest Vatican statement said the pope had slept well, waking shortly after 8 a.m. (7 a.m. GMT).
Francis' condition remains stable, with a moderately optimistic prognosis, meaning his life is not in danger.
An 88-year-old man with chronic lung disease who had surgery to remove part of his lung when he was younger suffered two respiratory crises on Monday that slowed his recovery.
The Vatican said it had been using supplemental oxygen on Tuesday after a respiratory crisis a day earlier, but had resumed using a breathing mask overnight.
Francis was hospitalized on February 14, his longest hospital stay in his 12-year papacy.
Sourse: breakingnews.ie